Gastrointestinal Hemorrhages in Patients With COVID-19 Managed With Transarterial Embolization
Ierardi, Anna Maria MD1; Del Giudice, Costantino MD2; Coppola, Andrea MD3; Carnevale, Aldo MD4; Giganti, Melchiore MD4; Renzulli, Matteo MD5; Tacher, Vania MD6; Urbano, Jose MD7; Kobeiter, Hicham MD6; Loffroy, Romaric MD8; Sapoval, Marc MD2; Carrafiello, Gianpaolo MD1,9
estern European countries have experienced a rapid and impressive surge of novel coronavirus disease 2019 (COVID-19) cases. Although the principal cause of mortality is acute respiratory insufficiency, concern exists over the association between severe acute respiratory syndrome coronavirus 2 infection and coagulopathy that can precipitate disseminated intravascular coagulation (1). Local thrombi in the lungs and other organs are considered to be distinctive of severe COVID-19, which are responsible for the clinical manifestations of the disease related to ischemic damage (2). Anticoagulants have therefore become part of the medical therapy in hospitalized patients, and this may increase the risk of spontaneous bleeding.
We describe the technical and clinical success as well as the safety profile of transarterialembolization (TAE) in the treatment of gastrointestinal (GI) bleedings inpatientswith COVID-19.
This was an international multicenter retrospective observational study (Radcovid05-2020-467-2020). Inclusion criteria were positivity for severe acute respiratory syndrome coronavirus 2 infection through reverse-transcriptase polymerase chain reaction tests, preoperative computed tomography demonstrating arterial GI bleeding, significant drop in hemoglobin level, and/or hemodynamic instability. All the staff involved had to follow a high-standard infection protection protocol during the procedures (3).
Technical success was defined as the disappearance of contrast extravasation or complete exclusion of the pseudoaneurysm at angiography performed at the end of the procedure.
Clinical success was defined as the achievement of hemostasis, associated with hemodynamic stability, without rebleeding or related mortality within 30 days after embolization.
From March to May 2020, in 16 frontline hospitals in Italy, France, and Spain, 11 consecutive patients (7 men, 4 women, median age of 65 years) underwent TAE for GI bleeding
Hypertension, cancer, and preadmission anticoagulation therapy were found to be the most frequent conditions associated with GI bleeding.
Enoxaparin was used in 9/10 patients (ranging from 4,000 units/24 h to 6,000 units/12 h), and 2 patients were on calciparine (0,3 mL/12 h).
Technical and clinical success was obtained in 100% and 90.9% of patients, respectively. Rebleeding occurred in 1 patient (9%) who needed a complementary endoscopy. Mortality rate within 30 days after embolization was 0%. Minor complications were recorded in 18.2% (2/11) including a groin hematoma and an ischemic rectal ulcer both managed conservatively.
In summary, the COVID-19 outbreak is rapidly changing patient workflow; in this setting, a close cooperation between interventional radiologists and the other health professionals involved in the management of these patients is fundamental to redistribute the workflow rationally and effectively and opportunely provide the best care possible. Recently, other cases of GI bleeding inpatientswith COVID-19 have been reported (4).
Although endoscopy could be curative, in severely ill patientswith COVID-19, the risks may outweigh the benefits (5). TAE in the management of GI bleedings is feasible, safe, and effective even inpatientswith COVID-19. Under these extreme circumstances, the implementation of interventional radiology procedures needs particular precautions to reduce the risk of transmission among the healthcare workers in interventional radiology units.
CONFLICTS OF INTEREST
Guarantor of the article: Anna Maria Ierardi, MD.
Specific author contributions: A.M.I. and G.C.: study concept and design. A.M.I., C.D.G., A. Coppola, H.K., V.T., J.U., and R.L.: acquisition of data. A.M.I. and A.Coppola: statistical analysis. A.M.I., M.G., and M.R.: interpretation of data. A.M.I., A. Coppola, and A. Carnevale: drafting of the manuscript. All coauthors: critical revision of the manuscript for important intellectual content. A.M.I. and G.C.: study supervision. All authors approved the final draft submitted.
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